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SUBUTEX:(buprenorphine) Sublingual Tablets
SUBUTEX (buprenorphine) sublingual tablet is an uncoated oval white flat bevelled edged tablet. Furthermore it is debossed with an alphanumeric word identifying the merchandise and strength on one side. It contains buprenorphine HCl, a partial agonist at the mu-opioid receptor.
However, which is out there in two dosage strengths, 2 mg buprenorphine and eight mg buprenorphine. (as the free base, like 2.16 mg buprenorphine hydrochloride USP and eight .64 mg buprenorphine hydrochloride USP). Each tablet also contains lactose, mannitol, cornstarch, povidone K30, acid , sodium citrate and magnesium stearate.
Also, chemically, buprenorphine HCl is (2S)-2-[17-Cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol hydrochloride. It has Buprenorphine HCl has the formula C29 H41 NO4 • HCl. Therefore the relative molecular mass is 504.10.
In addition, it’s a white or off-white crystalline powder, sparingly soluble in water, freely soluble in methanol, soluble in alcohol and practically insoluble in cyclohexane.
DOSAGE AND ADMINISTRATION
Drug Addiction Treatment Act
Moreover, under the white plague Treatment Act (DATA) codified at 21 U.S.C. 823(g), prescription use of this product within the treatment of opioid dependence is restricted to healthcare providers.
Dosage Forms And Strengths
buprenorphine 2 mg,
Storage And Handling
Nevertheless, NDC 12496-1310-2 (buprenorphine 8 mg/sublingual tablet; content expressed in terms of free base, like 8.64 mg buprenorphine hydrochloride USP) -30 tablets per bottle Store at 25°C (77°F), excursions permitted to 15°-30°C (59°-86°F). Also, advise patients to store buprenorphine-containing medications safely and out of sight and reach of youngsters and to destroy any unused medication appropriately
Although, after treatment induction and stabilization, the upkeep dose of SUBUTEX is usually within the range of 4 mg to 24 mg buprenorphine per day counting on the individual patient. The recommended target dosage of SUBUTEX is 16 mg as one daily dose.
Furthermore, Patients may require treatment indefinitely and will continue for as long as patients are benefiting and therefore the use of SUBUTEX contributes to the intended treatment goals.
Method Of Administration
Also, either way, the patients should still hold the tablets under the tongue until they dissolve; swallowing the tablets reduces the bioavailability of the drug. To make sure consistency in bioavailability, patients should follow an equivalent manner of dosing with continued use of the merchandise.
Nevertheless, this drug has found its wide application in substitution therapy for narcotic drugs, as well as for pain relief and pain relief. By its qualities, it is many times stronger than the drug Morphine.
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