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German chemists originally synthesized MDMA, or ecstasy, for pharmaceutical purposes in 1912. During the Cold War, the CIA experimented with MDMA as a psychological weapon. Ecstasy had become a popular party drug by the late 1980s, and it’s recreational use is often associated with rave culture, dance parties and electronic music festivals. Despite the illicit drug’s legal status, some medical researchers now believe MDMA could have therapeutic benefits, particularly among people with PTSD, depression and other behavioral issues.
German chemists discovered 3,4-methylenedioxymethamphetamine, or MDMA, in 1912 while developing other medicines that could stop bleeding.
The substance, they discovered, had unique psychoactive properties. The pharmaceutical company Merck patented MDMA in 1914 as a compound that could have pharmaceutical value. It would be several decades before further drug development would take place.
MK-Ultra, a CIA project started in the 1950s, worked on the application of psychedelics for mind control. The project became notorious for testing psychoactive drugs on unwitting subjects.
The CIA experimented with MDMA as part of MK-Ultra, but only tested the drug on non-human subjects. These experiments produced the first known toxicology studies of MDMA. The drug’s code name was EA-1475.
Therapeutic Uses of MDMA
In the 1970s, some psychiatrists began using MDMA as a psychotherapeutic tool.
They thought it made their patients more willing to communicate and participate in the psychotherapy process. Therapists called the drug “Adam,” because they felt it returned patients to a more innocent state.
But by the 1980s, ecstasy or molly had become more widely known as a party drug. In a 1984 article, the San Francisco Chronicle called the drug “the yuppie psychedelic,” because it was supposedly milder and less dangerous than LSD.